Abstract:

Objective

To study the effect of mild hypothermia on glutamic acid level in patient’s blood serum after the cerebral hemorrhage.

Methods

We selected 116 cases of cerebral hemorrhage from 2011 to 2012 in the Department of Neurosurgery, Heilongjiang Provincal Hospital Nangang Branch, and confirmed by head CT. We divided the cases into group A (mild hypothermia treatment) and group B (conventional treatment), each group have 58 patients. Mild hypothermia treatment with domestic HGT-200 mild hypothermia therapeutic instrument were applied to the patients in group A, the tank was injected into 2 500 ml distilled water and 500 ml 95% ethanol. Only conventional treatment (trophic nerve and routine dehydration) was applied to the patients in group B.The glutamic acid level in 24 h and 6 d after admission was analyzed in patient's blood serum by the high performance liquid chromatography to compare the situation of clinical outcomes and complications.Serum glutamic acid level among groups was tested by t test,the total effective rate and the incidence of complications among groups was tested by χ² test.

Results

The level of glutamic acid in group A was lower than that in group B at both time point of 24 h(84.6±2.6μmol/L vs 114.4±3.6μmol/L, t=31.269, P＜0.05) and 6 d(104.6±3.2μmol/L vs 190.3±4.7μmol/L, t=37.413, P＜0.05).The total effective rate of group A was 84.48% (49/58), mortality of group A was 8.62% (5/58), the total effective rate of group B was 48.27% (28/58), mortality of group B was 36.21% (21/58), the difference on both total effective rate and mortality among groups are significant (χ²=17.032、12.691，P＜0.01). Complications, 27 cases in group A and 28 cases in group B, and there was no statistical significance of difference among groups (χ²=1.254, P>0.05).

Conclusions

Mild hypothermia treatment may be an effective method to degrade the level of glutamic acid in patient's blood serum and alleviate brain injuries.The mild hypothermia therapy may improve outcomes of patients.

Key words: Cerebral hemorrhage, Hypothermia, induced, Glutamic acid, Chromatography,high pressure liquid, Comparative effectiveness research