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Chinese Journal of Neurotraumatic Surgery(Electronic Edition) ›› 2022, Vol. 08 ›› Issue (04): 247-251. doi: 10.3877/cma.j.issn.2095-9141.2022.04.010

• Review • Previous Articles     Next Articles

Research progress and prospect of cinnamaldehyde inhibiting tumor by HIF-1α

Zhiwen Wang1, Changfeng Wang1, Haijiang Wang2,()   

  1. 1. Department of Neurosurgery, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, Nanchang 330006, China
    2. Department of Neurosurgery, the 7 Medical Center, PLA General Hospital, Beijing 100700, China
  • Received:2022-03-26 Online:2022-08-15 Published:2022-09-05
  • Contact: Haijiang Wang

Abstract:

At present, great progress has been made in the treatment of cancer, but the prognosis has not improved much. Traditional Chinese medicine has received more attention in recent years, and some herbal extracts have been proven to have good anti-tumor effects. The main ingredient of cinnamon is cinnamaldehyde (CA), which has been shown to inhibit a variety of cancers. Tumor microenvironment is a new direction of cancer treatment, in particular, the role of hypoxia inducible factor-1α (HIF-1α) has been widely discussed, but there is a lack of a systematic summary of CA and HIF-1α in tumors, and there are few reports on CA inhibiting gliomas. This review mainly summarizeds the mechanism of CA treating tumor and HIF-1α related research progress in recent years, and discusses the prospect of CA for the treatment of glioma.

Key words: Cinnamaldehyde, Hypoxia inducible factor-1α, Tumor, Glioma

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