Clinical study on cognitive function and prognosis of patients with ruptured anterior communicating artery aneurysm after operation

doi:10.3877/cma.j.issn.2095-9141.2020.05.002

Abstract

Abstract:

Objective

To investigate the cognitive function and prognosis of patients with ruptured anterior communicating aneurysm after surgical treatment.

Methods

Retrospective analysis was made on the clinical data of 94 consecutive patients with ruptured anterior communicating aneurysm admitted to Neurosurgery Department of The First Hospital of Shanxi Medical University from March 2015 to June 2017. The cognitive function and prognosis of postoperative patients were evaluated by means of telephone interview for cognitive status-modified, instrumental daily living ability scale and modified Rankin scale. Univariate analysis and multifactorial Logistic regression analysis were used to analyze the influencing factors of postoperative patients’cognitive function and prognosis.

Results

Follow-up evaluation of postoperative cognitive function and prognosis was completed in 67 patients. Univariate analysis: Hunt-Hess grade and degree of education were influential factors for postoperative cognitive function in patients (P<0.05). Hunt-Hess grade, Fisher grade, age and degree of education were influential factors for prognosis of the patients (P<0.05). Further multi-factor Logistic analysis showed that high education level was an independent factor affecting postoperative cognitive function of patients (OR=0.073, 95%CI: 0.008-0.638, P=0.018).

Conclusion

High educational level is an independent and protective factor of postoperative cognitive function.

Key words: Intracranial aneurysm, Craniotomy, Interventional therapy, Cognitive impairment

Shizhou Wang, Xinjuan Xu, Ce Wang, Keke Wang, Xintao Huang, Ning Ma, Aihua Liu. Clinical study on cognitive function and prognosis of patients with ruptured anterior communicating artery aneurysm after operation[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2020, 06(05): 259-264.

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Figures/Tables 2

References 31

[1]	Jagadeesan BD, Delgado Almandoz JE, Kadkhodayan Y, et al. Size and anatomic location of ruptured intracranial aneurysms in patients with single and multiple aneurysms: a retrospective study from a single center[J]. J Neurointerv Surg, 2014, 6(3): 169-174.
[2]	万大海，杨钰桢，马宁.影响经翼点入路夹闭破裂前交通动脉动脉瘤预后的临床因素分析[J].中华神经外科杂志, 2019, 35(7): 708-711.
[3]	耿建国，张玉勇.前交通动脉瘤不同手术治疗的疗效及对患者认知功能的影响[J].中国实用神经疾病杂志, 2015, 18(24): 81-82.
[4]	Frazer D, Ahuja A, Watkins L, et al. Coiling versus clipping for the treatment of aneurysmal subarachnoid hemorrhage: a longitudinal investigation into cognitive outcome[J]. Neurosurgery, 2007, 60(3): 434-441; discussion 441-432.
[5]	Santiago-Ramajo S, Katati MJ, Perez-Garcia M, et al. Neuropsychological evaluation of the treatments applied to intracranial aneurysms in a Spanish sample[J]. J Clin Exp Neuropsychol, 2007, 29(6): 634-641.
[6]	Nassiri F, Workewych AM, Badhiwala JH, et al. Cognitive outcomes after anterior communicating artery aneurysm repair[J]. Can J Neurol Sci, 2018, 45(4): 415-423.
[7]	Al-Khindi T, Macdonald RL, Schweizer TA. Cognitive and functional outcome after aneurysmal subarachnoid hemorrhage[J]. Stroke, 2010, 41(8): e519-e536.
[8]	Zanaty M, Nakagawa D, Starke RM, et al. Intraventricular extension of an aneurysmal subarachnoid hemorrhage is an independent predictor of a worse functional outcome[J]. Clin Neurol Neurosurg, 2018, 170: 67-72.
[9]	Reijmer YD, van den Heerik MS, Heinen R, et al. Microstructural white matter abnormalities and cognitive impairment after aneurysmal subarachnoid hemorrhage[J]. Stroke, 2018, 49(9): 2040-2045.
[10]	Lucke-Wold BP, Logsdon AF, Manoranjan B, et al. Aneurysmal subarachnoid hemorrhage and neuroinflammation: a comprehensive review[J]. Int J Mol Sci, 2016, 17(4): 497.
[11]	Pinto TCC, Machado L, Bulgacov TM, et al. Influence of age and education on the performance of elderly in the brazilian version of the montreal cognitive assessment battery[J]. Dement Geriatr Cogn Disord, 2018, 45(5-6): 290-299.
[12]	Guerra-Carrillo B, Katovich K, Bunge SA. Does higher education hone cognitive functioning and learning efficacy? Findings from a large and diverse sample[J]. PLoS One, 2017, 12(8): e0182276.
[13]	Kotekar N, Shenkar A, Nagaraj R. Postoperative cognitive dysfunction-current preventive strategies[J]. Clin Interv Aging, 2018, 13: 2267-2273.
[14]	O’Neill AH, Chandra RV, Lai LT. Safety and effectiveness of microsurgical clipping, endovascular coiling, and stent assisted coiling for unruptured anterior communicating artery aneurysms: a systematic analysis of observational studies[J]. J Neurointerv Surg, 2017, 9(8): 761-765.
[15]	Heit JJ, Ball RL, Telischak NA, et al. Patient outcomes and cerebral infarction after ruptured anterior communicating artery aneurysm treatment[J]. AJNR Am J Neuroradiol, 2017, 38(11): 2119-2125.
[16]	Mortimer AM, Steinfort B, Faulder K, et al. Rates of local procedural-related structural injury following clipping or coiling of anterior communicating artery aneurysms[J]. J Neurointerv Surg, 2016, 8(3): 256-264.
[17]	Deutsch BC, Neifert SN, Caridi JM. No disparity in outcomes between surgical clipping and endovascular coiling after aneurysmal subarachnoid hemorrhage[J]. World Neurosurg, 2018, 120: e318-e325.
[18]	Lindgren A, Turner EB, Sillekens T, et al. Outcome after clipping and coiling for aneurysmal subarachnoid hemorrhage in clinical practice in Europe, USA, and Australia[J]. Neurosurgery, 2019, 84(5): 1019-1027.
[19]	Mahaney KB, Brown RD, Jr, Meissner I, et al. Age-related differences in unruptured intracranial aneurysms: 1-year outcomes[J]. J Neurosurg, 2014, 121(5): 1024-1038.
[20]	王栋，鹿海龙，王心刚,等.影响介入栓塞与开颅瘤颈夹闭术治疗颅内动脉瘤患者预后的危险因素分析[J].神经损伤与功能重建, 2020, 15(1): 39-41.
[21]	Veldeman M, Hollig A, Clusmann H, et al. Delayed cerebral ischaemia prevention and treatment after aneurysmal subarachnoid haemorrhage: a systematic review[J]. Br J Anaesth, 2016, 117(1): 17-40.
[22]	Fujii M, Yan J, Rolland WB, et al. Early brain injury, an evolving frontier in subarachnoid hemorrhage research[J]. Transl Stroke Res, 2013, 4(4): 432-446.
[23]	Witsch J, Frey HP, Patel S, et al. Prognostication of long-term outcomes after subarachnoid hemorrhage: the FRESH score[J]. Ann Neurol, 2016, 80(1): 46-58.
[24]	邱方方，陆远强.影响动脉瘤性蛛网膜下腔出血的预后因素分析[J].中华急诊医学杂志, 2019, 28(3): 379-383.
[25]	Froehner M, Koch R, Propping S, et al. Level of education and mortality after radical prostatectomy[J]. Asian J Androl, 2017, 19(2): 173-177.
[26]	Puigpinós R, Borrell C, Antunes JLF, et al. Trends in socioeconomic inequalities in cancer mortality in Barcelona: 1992-2003[J]. BMC Public Health, 2009, 9(1): 35.
[27]	Abdoli G, Bottai M, Moradi T. Cancer mortality by country of birth, sex, and socioeconomic position in Sweden, 1961-2009[J]. PLoS One, 2014, 9(3): e93174.
[28]	吕志红，刘晓加.认知功能电话问卷修订版在缺血性脑卒中后认知功能研究中的应用[J].中华神经医学杂志, 2016, 15(6): 604-609.
[29]	Lacruz ME, Bickel H, Emeny RT, et al. Feasibility, internal consistency and covariates of TICS-m (telephone interview for cognitive status-modified) in a population-based sample: findings from the KORA-age study[J]. Int J Geriatr Psychiatry, 2013, 28(9): 971-978.
[30]	Bentvelzen AC, Crawford JD, Theobald A, et al. Validation and normative data for the modified telephone interview for cognitive status: the sydney memory and ageing study[J]. J Am Geriatr Soc, 2019, 67(10): 2108-2115.
[31]	孟超，张新卿，周景升,等.认知功能电话问卷修订版(TICS-m)在痴呆测查中的应用[J].中国心理卫生杂志, 2005, 19(1): 34-37.

项目		TICS-m评分				IADL评分				mRs评分
项目		≥33分	<33分	Z/χ²值	P值	≥5分	<5分	Z/χ²值	P值	≤2分	>2分	Z/χ²值	P值
开颅与介入[例(%)]		?	?	0.322	0.570	?	?	2.504	0.114	?	?	7.013	0.008
?	开颅夹闭	14(73.7)	36(75.0)	?	?	47(78.3)	3(42.9)	?	?	47(81.0)	3(33.3)	?	?
?	介入栓塞	6(26.3)	11(25.0)	?	?	13(21.7)	4(57.1)	?	?	11(19.0)	6(66.7)	?	?
开颅侧别[例(%)]		?	?	1.654	0.198	?	?	0.518	0.412	?	?	0.518	0.412
?	左侧	7(50.0)	25(69.4)	?	?	29(61.7)	3(100)	?	?	29(61.7)	3(100)	?	?
?	右侧	7(50.0)	11(30.6)	?	?	18(38.3)	0(0)	?	?	18(38.3)	0(0)	?	?
切除直回[例(%)]		?	?	0.000	1.000	?	?	0.000	1.000	?	?	0.000	1.000
?	切除	9(64.3)	16(44.4)	?	?	23(48.9)	2(66.7)	?	?	23(48.9)	2(66.7)	?	?
?	未切除	5(35.7)	20(55.6)	?	?	24(51.1)	1(33.3)	?	?	24(51.1)	1(33.3)	?	?
使用支架[例(%)]		?	?	-	0.280	?	?	-	1.000	?	?	-	1.000
?	支架辅助	3(60.0)	3(25.0)	?	?	5(38.5)	1(25.0)	?	?	4(36.4)	2(33.3)	?	?
?	无支架辅助	2(40.0)	9(75.0)	?	?	8(61.5)	3(75.0)	?	?	7(63.6)	4(66.7)	?	?
性别（男/女）		11/8	29/19	1.618	0.203	32/26	8/1	1.869	0.172	32/26	8/1	1.869	0.172
年龄[岁，M(IQR)]		49.5(14.0)	50(14.0)	-0.288	0.773	49.5(15.0)	56(11.0)	-2.257	0.024	49.5(14.0)	56(12.0)	-2.190	0.029
动脉瘤最长径[岁，M(IQR)]		4(1.4)	3.8(3.5)	-0.558	0.577	4(2.5)	4(4)	-0.524	0.600	4(2.8)	3.4(2.8)	-0.037	0.971
Hunt-Hess分级[例(%)]		?	?	8.924	0.012	?	?	10.291	0.006	?	?	9.538	0.008
?	Ⅰ级	5(25.0)	19(40.4)	?	?	22(36.7)	2(28.6)	?	?	22(37.9)	2(22.2)	?	?
?	Ⅱ级	11(55.0)	18(38.3)	?	?	27(45.0)	1(14.3)	?	?	26(44.8)	2(22.2)	?	?
?	Ⅲ级	4(20.0)	10(21.3)	?	?	11(18.3)	4(57.1)	?	?	10(17.3)	5(55.6)	?	?
Fisher分级[例(%)]		?	?	5.070	0.079	?	?	10.774	0.005	?	?	3.708	0.157
?	2	13(65.0)	31(66.0)	?	?	41(68.3)	3(42.9)	?	?	39(67.2)	5(55.6)	?	?
?	3	5(25.0)	9(19.1)	?	?	14(23.3)	0(0.0)	?	?	14(24.1)	0(0.0)	?	?
?	4	2(10.0)	7(14.9)	?	?	5(83.4)	4(57.1)	?	?	5(8.6)	4(44.4)	?	?
高血压[例(%)]		8(42.1)	20(41.7)	0.001	0.974	23(39.7)	5(55.6)	0.228	0.592	23(39.7)	5(55.6)	0.228	0.592
饮酒[例(%)]		7(36.8)	16(32.0)	0.074	0.785	22(36.7)	1(14.3)	0.577	0.448	21(36.2)	2(22.2)	0.198	0.656
吸烟[例(%)]		9(47.4)	18(37.5)	0.551	0.458	25(42.7)	2(28.6)	0.068	0.794	24(41.4)	3(33.3)	0.009	0.926
动脉瘤分型[例(%)]		?	?	0.237	0.626	?	?	0.852	0.356	?	?	1.133	0.287
?	上凸型	14(70.0)	30(63.8)	?	?	41(68.3)	3(42.9)	?	?	40(69.0)	4(44.4)	?	?
?	下凸型	6(30.0)	17(36.2)	?	?	19(31.7)	4(57.1)	?	?	18(31.0)	5(55.6)	?	?
术后脑挫伤[例(%)]		?	?	0.612	0.434	?	?	-	1.000	?	?	-	1.000
?	无挫伤	20(100.0)	43(91.5)	?	?	56(93.3)	7(100.0)	?	?	54(93.1)	9(100.0)	?	?
?	有挫伤	0(0.0)	4(8.5)	?	?	4(6.7)	0(0.0)	?	?	4(6.9)	0(0.0)	?	?
术后脑梗死[例(%)]		?	?	0.870	0.768	?	?	0.455	0.500	?	?	0.000	1.000
?	无	9(45.0)	23(48.9)	?	?	30(50.0)	2(28.6)	?	?	28(48.3)	4(44.4)	?	?
?	有	11(55.0)	24(51.1)	?	?	30(50.0)	5(71.4)	?	?	30(51.7)	5(55.6)	?	?
术后脑积水[例(%)]		?	?	0.000	1.000	?	?	-	0.556	?	?	-	1.000
?	无	18(90.0)	42(89.4)	?	?	54(90.0)	6(85.7)	?	?	52(89.7)	8(88.9)	?	?
?	有	2(10.0)	5(10.6)	?	?	6(10.0)	1(14.3)	?	?	6(10.3)	1(11.1)	?	?
文化程度[例(%)]		?	?	11.456	0.003	?	?	7.020	0.030	?	?	6.692	0.035
?	小学	2(10.0)	17(36.2)	?	?	14(23.3)	5(71.4)	?	?	13(22.4)	6(66.7)	?	?
?	中学	13(65.0)	27(57.4)	?	?	38(63.3)	2(28.6)	?	?	37(63.8)	3(33.3)	?	?
?	大学及以上	5(25.0)	3(6.4)	?	?	8(13.3)	0(0.0)	?	?	8(17.8)	0(0.0)	?	?

项目		TICS-m评分				IADL评分				mRs评分
项目		≥33分	<33分	Z/χ²值	P值	≥5分	<5分	Z/χ²值	P值	≤2分	>2分	Z/χ²值	P值
开颅与介入[例(%)]		?	?	0.322	0.570	?	?	2.504	0.114	?	?	7.013	0.008
?	开颅夹闭	14(73.7)	36(75.0)	?	?	47(78.3)	3(42.9)	?	?	47(81.0)	3(33.3)	?	?
?	介入栓塞	6(26.3)	11(25.0)	?	?	13(21.7)	4(57.1)	?	?	11(19.0)	6(66.7)	?	?
开颅侧别[例(%)]		?	?	1.654	0.198	?	?	0.518	0.412	?	?	0.518	0.412
?	左侧	7(50.0)	25(69.4)	?	?	29(61.7)	3(100)	?	?	29(61.7)	3(100)	?	?
?	右侧	7(50.0)	11(30.6)	?	?	18(38.3)	0(0)	?	?	18(38.3)	0(0)	?	?
切除直回[例(%)]		?	?	0.000	1.000	?	?	0.000	1.000	?	?	0.000	1.000
?	切除	9(64.3)	16(44.4)	?	?	23(48.9)	2(66.7)	?	?	23(48.9)	2(66.7)	?	?
?	未切除	5(35.7)	20(55.6)	?	?	24(51.1)	1(33.3)	?	?	24(51.1)	1(33.3)	?	?
使用支架[例(%)]		?	?	-	0.280	?	?	-	1.000	?	?	-	1.000
?	支架辅助	3(60.0)	3(25.0)	?	?	5(38.5)	1(25.0)	?	?	4(36.4)	2(33.3)	?	?
?	无支架辅助	2(40.0)	9(75.0)	?	?	8(61.5)	3(75.0)	?	?	7(63.6)	4(66.7)	?	?
性别（男/女）		11/8	29/19	1.618	0.203	32/26	8/1	1.869	0.172	32/26	8/1	1.869	0.172
年龄[岁，M(IQR)]		49.5(14.0)	50(14.0)	-0.288	0.773	49.5(15.0)	56(11.0)	-2.257	0.024	49.5(14.0)	56(12.0)	-2.190	0.029
动脉瘤最长径[岁，M(IQR)]		4(1.4)	3.8(3.5)	-0.558	0.577	4(2.5)	4(4)	-0.524	0.600	4(2.8)	3.4(2.8)	-0.037	0.971
Hunt-Hess分级[例(%)]		?	?	8.924	0.012	?	?	10.291	0.006	?	?	9.538	0.008
?	Ⅰ级	5(25.0)	19(40.4)	?	?	22(36.7)	2(28.6)	?	?	22(37.9)	2(22.2)	?	?
?	Ⅱ级	11(55.0)	18(38.3)	?	?	27(45.0)	1(14.3)	?	?	26(44.8)	2(22.2)	?	?
?	Ⅲ级	4(20.0)	10(21.3)	?	?	11(18.3)	4(57.1)	?	?	10(17.3)	5(55.6)	?	?
Fisher分级[例(%)]		?	?	5.070	0.079	?	?	10.774	0.005	?	?	3.708	0.157
?	2	13(65.0)	31(66.0)	?	?	41(68.3)	3(42.9)	?	?	39(67.2)	5(55.6)	?	?
?	3	5(25.0)	9(19.1)	?	?	14(23.3)	0(0.0)	?	?	14(24.1)	0(0.0)	?	?
?	4	2(10.0)	7(14.9)	?	?	5(83.4)	4(57.1)	?	?	5(8.6)	4(44.4)	?	?
高血压[例(%)]		8(42.1)	20(41.7)	0.001	0.974	23(39.7)	5(55.6)	0.228	0.592	23(39.7)	5(55.6)	0.228	0.592
饮酒[例(%)]		7(36.8)	16(32.0)	0.074	0.785	22(36.7)	1(14.3)	0.577	0.448	21(36.2)	2(22.2)	0.198	0.656
吸烟[例(%)]		9(47.4)	18(37.5)	0.551	0.458	25(42.7)	2(28.6)	0.068	0.794	24(41.4)	3(33.3)	0.009	0.926
动脉瘤分型[例(%)]		?	?	0.237	0.626	?	?	0.852	0.356	?	?	1.133	0.287
?	上凸型	14(70.0)	30(63.8)	?	?	41(68.3)	3(42.9)	?	?	40(69.0)	4(44.4)	?	?
?	下凸型	6(30.0)	17(36.2)	?	?	19(31.7)	4(57.1)	?	?	18(31.0)	5(55.6)	?	?
术后脑挫伤[例(%)]		?	?	0.612	0.434	?	?	-	1.000	?	?	-	1.000
?	无挫伤	20(100.0)	43(91.5)	?	?	56(93.3)	7(100.0)	?	?	54(93.1)	9(100.0)	?	?
?	有挫伤	0(0.0)	4(8.5)	?	?	4(6.7)	0(0.0)	?	?	4(6.9)	0(0.0)	?	?
术后脑梗死[例(%)]		?	?	0.870	0.768	?	?	0.455	0.500	?	?	0.000	1.000
?	无	9(45.0)	23(48.9)	?	?	30(50.0)	2(28.6)	?	?	28(48.3)	4(44.4)	?	?
?	有	11(55.0)	24(51.1)	?	?	30(50.0)	5(71.4)	?	?	30(51.7)	5(55.6)	?	?
术后脑积水[例(%)]		?	?	0.000	1.000	?	?	-	0.556	?	?	-	1.000
?	无	18(90.0)	42(89.4)	?	?	54(90.0)	6(85.7)	?	?	52(89.7)	8(88.9)	?	?
?	有	2(10.0)	5(10.6)	?	?	6(10.0)	1(14.3)	?	?	6(10.3)	1(11.1)	?	?
文化程度[例(%)]		?	?	11.456	0.003	?	?	7.020	0.030	?	?	6.692	0.035
?	小学	2(10.0)	17(36.2)	?	?	14(23.3)	5(71.4)	?	?	13(22.4)	6(66.7)	?	?
?	中学	13(65.0)	27(57.4)	?	?	38(63.3)	2(28.6)	?	?	37(63.8)	3(33.3)	?	?
?	大学及以上	5(25.0)	3(6.4)	?	?	8(13.3)	0(0.0)	?	?	8(17.8)	0(0.0)	?	?

项目	因素	分级	β值	SE值	Wald值	OR值	95%Cl	P值
?	?	小学	?	?	?	1(Ref)	?	?
?	文化程度	中学	-1.356	0.904	2.252	0.258	0.440~1.514	0.133
?	?	大学及以上	-2.612	1.101	5.624	0.073	0.008~0.638	0.018
?	?	2级	?	?	?	1(Ref)	?	?
TICS-m评分	Fisher分级	3级	0.678	0.978	0.481	1.849	0.279~12.262	0.524
TICS-m评分	?	4级	0.399	1.078	0.099	1.103	0.170~11.595	0.753
?	?	Ⅰ级	?	?	?	1(Ref)	?	?
?	Hunt-Hess分级	Ⅱ级	-0.814	0.901	0.019	0.443	0.076~2.558	0.366
?	?	Ⅲ级	0.107	0.780	0.019	1.400	0.313~5.135	0.891
?	年龄	-	-0.015	0.031	0.237	0.985	0.927~1.047	0.627
?	?	2级	?	?	?	1(Ref)	?	?
?	Fisher分级	3级	2.258	1.248	3.272	10.412	0.942~115.109	0.056
?	?	4级	4.695	10.015	0.011	97.200	0.001~1000.21	0.998
IADL评分	?	Ⅰ级	?	?	?	1(Ref)	?	?
?	Hunt-Hess分级	Ⅱ级	0.864	1.261	0.469	4.847	0.300~78.442	0.266
?	?	Ⅲ级	1.683	1.427	1.391	5.380	0.328~88.205	0.238
?	年龄	-	-0.130	0.068	3.682	0.875	0.766~1000.000	0.050
?	?	2级	?	?	?	1(Ref)	?	?
?	Fisher分级	3级	1.130	1.103	1.050	3.609	0.446~29.231	0.229
?	?	4级	1.738	1.421	1.126	4.128	0.578~33.212	0.315
mRs评分	?	Ⅰ级	?	?	?	1(Ref)	?	?
?	Hunt-Hess分级	Ⅱ级	1.883	1.155	2.656	2.401	0.627~54.246	0.103
?	?	Ⅲ级	1.763	1.138	2.401	4.629	0.530~40.461	0.166
?	年龄	-	-0.098	0.053	3.454	0.904	0.814~1.004	0.059

项目	因素	分级	β值	SE值	Wald值	OR值	95%Cl	P值
?	?	小学	?	?	?	1(Ref)	?	?
?	文化程度	中学	-1.356	0.904	2.252	0.258	0.440~1.514	0.133
?	?	大学及以上	-2.612	1.101	5.624	0.073	0.008~0.638	0.018
?	?	2级	?	?	?	1(Ref)	?	?
TICS-m评分	Fisher分级	3级	0.678	0.978	0.481	1.849	0.279~12.262	0.524
TICS-m评分	?	4级	0.399	1.078	0.099	1.103	0.170~11.595	0.753
?	?	Ⅰ级	?	?	?	1(Ref)	?	?
?	Hunt-Hess分级	Ⅱ级	-0.814	0.901	0.019	0.443	0.076~2.558	0.366
?	?	Ⅲ级	0.107	0.780	0.019	1.400	0.313~5.135	0.891
?	年龄	-	-0.015	0.031	0.237	0.985	0.927~1.047	0.627
?	?	2级	?	?	?	1(Ref)	?	?
?	Fisher分级	3级	2.258	1.248	3.272	10.412	0.942~115.109	0.056
?	?	4级	4.695	10.015	0.011	97.200	0.001~1000.21	0.998
IADL评分	?	Ⅰ级	?	?	?	1(Ref)	?	?
?	Hunt-Hess分级	Ⅱ级	0.864	1.261	0.469	4.847	0.300~78.442	0.266
?	?	Ⅲ级	1.683	1.427	1.391	5.380	0.328~88.205	0.238
?	年龄	-	-0.130	0.068	3.682	0.875	0.766~1000.000	0.050
?	?	2级	?	?	?	1(Ref)	?	?
?	Fisher分级	3级	1.130	1.103	1.050	3.609	0.446~29.231	0.229
?	?	4级	1.738	1.421	1.126	4.128	0.578~33.212	0.315
mRs评分	?	Ⅰ级	?	?	?	1(Ref)	?	?
?	Hunt-Hess分级	Ⅱ级	1.883	1.155	2.656	2.401	0.627~54.246	0.103
?	?	Ⅲ级	1.763	1.138	2.401	4.629	0.530~40.461	0.166
?	年龄	-	-0.098	0.053	3.454	0.904	0.814~1.004	0.059

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