Research progress on the role of small Maf transcription factors in neurological diseases

doi:10.3877/cma.j.issn.2095-9141.2020.02.011

Abstract

Abstract:

Small Maf transcription factors (sMafs), including MafF, MafG, and MafK, are a group of highly homologous proteins containing a basic leucine zipper structure. Due to their lack of a transcription activation domain, sMafs mainly interact with Cap'n’Collar and Bach proteins form heterodimers, as well as homodimers between themselves. Oxidative stress and inflammatory response are common features in neurological diseases and have damaging effects on nerve injury, neurocognition, neurodevelopment, and other neural functions. sMafs play a protective role in oxidative stress and inflammatory response. In this paper, the antioxidation and anti-inflammatory effects of sMafs in neurological diseases, as well as their mechanisms of neurological damage, cognition, development and other aspects are reviewed.

Key words: Small Maf transcription factors, Neurological diseases, Oxidative stress, Inflammation

Fei Gao, Baiyun Liu, Xiang Mao. Research progress on the role of small Maf transcription factors in neurological diseases[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2020, 06(02): 113-117.

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