To investigate the correlation between serum levels of interleukin-12 (IL-12), interleukin-27 (IL-27), complement C1q tumor necrosis factor-related protein 3 (CTRP-3) and D-dimer (D-D) in patients with cerebral hemorrhage.

One hundred and six patients with hypertensive intracerebral hemorrhage admitted to Department of Neurosurgery, Dongying People’s Hospital of Shandong Province from July 2016 to May 2018 were selected. Eighty healthy persons were selected as control group. The IL-12, IL-27, CTRP-3, D-D levels of patients with different GCS scores and prognosis were compared, and Pearson correlation analysis was performed.

Compared with control group, the levels of IL-12, IL-27 and D-D in intracerebral hemorrhage group were significantly higher, CTRP-3 was lower (P<0.05). With the decrease of GCS score, the level of IL-12, IL-27 and D-D in patients with intracerebral hemorrhage increased continuously, CTRP-3 decreased (P<0.05). Compared with NIHSS≤12 patients, the levels of IL-12, IL-27, D-D in patients with NIHSS>12 were significantly higher, CTRP-3 was significantly lower (P<0.05). Compared with poor prognosis patients, the levels of IL-12, IL-27, D-D in patients with good prognosis were significantly lower, CTRP-3 was significantly higher (P<0.05). By Pearson correlation analysis, IL-12, IL-27, D-D were positively correlated with GCS and NIHSS score, and CTRP-3 was negatively correlated with GCS and NIHSS score (P<0.05).

The level of IL-12, IL-27, CTRP-3, D-D in patients with intracerebral hemorrhage is closely related to the degree of brain injury, which may indicate the prognosis.