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中华神经创伤外科电子杂志 ›› 2024, Vol. 10 ›› Issue (04) : 226 -232. doi: 10.3877/cma.j.issn.2095-9141.2024.04.006

临床研究

CT灌注成像参数及血栓弹力图对急性前循环脑梗死早期神经功能恶化的预测价值分析
李刚1,(), 潘晓帆1, 田雪1, 刘路路1   
  1. 1.241000 江苏无锡,无锡市惠山区人民医院(南通大学杏林学院附属惠山医院)神经内科
  • 收稿日期:2023-12-13 出版日期:2024-08-15
  • 通信作者: 李刚
  • 基金资助:
    无锡市卫生健康委面上科研项目(M202232)

Predictive value of CT perfusion imaging parameters and thromboelogram for early neurological deterioration of acute anterior circulatory cerebral infarction

Gang Li1,(), Xiaofan Pan1, Xue Tian1, LuLu Liu1   

  1. 1.Department of Neurology, Wuxi Huishan District People's Hospital (Affiliated Huishan Hospital of Xinglin College,Nantong University),Wuxi 241000,China
  • Received:2023-12-13 Published:2024-08-15
  • Corresponding author: Gang Li
引用本文:

李刚, 潘晓帆, 田雪, 刘路路. CT灌注成像参数及血栓弹力图对急性前循环脑梗死早期神经功能恶化的预测价值分析[J]. 中华神经创伤外科电子杂志, 2024, 10(04): 226-232.

Gang Li, Xiaofan Pan, Xue Tian, LuLu Liu. Predictive value of CT perfusion imaging parameters and thromboelogram for early neurological deterioration of acute anterior circulatory cerebral infarction[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2024, 10(04): 226-232.

目的

探讨CT 灌注成像(CTP)参数及血栓弹力图(TEG)对急性前循环脑梗死早期神经功能恶化(END)的预测价值。

方法

选取无锡市惠山区人民医院神经内科自2021 年2 月至2023 年2 月收治的149 例急性前循环脑梗死患者为研究对象。按照入院3 d 内是否发生END 将患者分为END组和无END组,比较2组患者美国国立卫生研究院卒中量表(NIHSS)评分、缺血区达峰时间(TTP)、脑血容量(CBV)、脑血流量(CBF)、动力时间(KT)、反应时间(RT);比较不同脑卒中病因的CTP 参数和TEG 参数。采用Pearson 法分析NIHSS 评分与CBV、TTP、CBF、RT、KT 的相关性;采用多因素二元Logistic 回归模型分析急性前循环脑梗死患者END 的独立影响因素;建立ROC 曲线分析CTP、TEG 相关指标的预测效能。

结果

149 例患者中,END 组26 例,无END 组123 例,2 组患者的NIHSS 评分比较,差异有统计学意义(P<0.05)。END 组患者的缺血区TTP、CBV、CBF 均高于无END 组,KT、RT 均少于无END 组,差异均有统计学意义(P<0.05)。经Pearson 法分析,NIHSS评分与TTP、CBV、CBF 呈正相关,与RT 呈负相关(P<0.05)。二元Logistic 回归模型分析显示,TTP、CBV、CBF、KT、RT 是急性前循环脑梗死患者END 的独立影响因素。ROC 曲线分析显示,TTP、CBV、CBF、KT、RT 及5 项指标联合预测急性前循环脑梗死患者END 的AUC 分别为0.759、0.694、0.758、0.736、0.794、0.965。5 项指标联合的AUC 分别与TTP、CBV、CBF、KT、RT 的AUC 比较,差异均有统计学意义(P<0.05)。

结论

CTP、TEG 能够有效预测急性前循环脑梗死患者END,对改善预后有一定价值。

Objective

To explore the predictive value of CT perfusion imaging (CTP) parameters and thromboelogram (TEG) for early neurological deterioration (END) in acute anterior circulation cerebral infarction.

Methods

A total of 149 patients with acute anterior circulation cerebral infarction admitted to Neurology Department of Wuxi Huishan District People's Hospital from February 2021 to February 2023 were selected as the research subjects. Patients were divided into END group and non END group based on whether END occurred within 3 d of admission. The National Institutes of Health stroke scale (NIHSS) scores, time to peak ischemic zone (TTP), cerebral blood volume (CBV), cerebral blood flow(CBF),dynamic time(KT),and reaction time(RT)were compared between the two groups;CTP parameters and thromboelogram parameters for different causes of stroke were compared. Pearson method was used to analyze the correlation between NIHSS score and CBV, TTP, CBF, RT, KT; The multi factor binary Logistic regression model was used to analyze the independent influencing factors of END in patients with acute anterior circulation cerebral infarction; ROC curve was established to analyze the predictive performance of CTP and TEG related indicators.

Results

Among the 149 patients, there were 26 patients in the END group and 123 patients in the non END group. The difference in NIHSS scores between the two groups was statistically significant (P<0.05). The TTP, CBV, and CBF in the ischemic area of patients in the END group were higher than those in the non END group, while KT and RT were lower than those in the non END group, and the differences were statistically significant (P<0.05). According to Pearson analysis, NIHSS score was positively correlated with TTP, CBV, and CBF,and negatively correlated with RT (P<0.05). The binary Logistic regression model analysis showed that TTP,CBV,CBF,KT,and RT were independent influencing factors of END in patients with acute anterior circulation cerebral infarction.ROC curve analysis showed that the AUC of TTP,CBV,CBF,KT,RT,and their combined prediction of END in patients with acute anterior circulation cerebral infarction were 0.759, 0.694, 0.758, 0.736, 0.794, and 0.965, respectively. The AUC of the combination of 5 indicators was compared with the AUC of TTP, CBV, CBF, KT, and RT, and the differences were statistically significant (P<0.05).

Conclusion

CTP and TEG can effectively predict the END of patients with acute anterior circulation cerebral infarction,and have certain prognostic value.

表1 2组患者的一般资料比较
Tab.1 Comparison of general information between two groups
表2 2组患者的缺血区CTP参数和TEG相关指标比较(± s
Tab.2 Comparison of ischemic zone CTP parameters and TEG indicators between two groups (Mean±SD)
表3 不同脑卒中病因的缺血区CTP参数和TEG相关指标比较(± s
Tab.3 Comparison of ischemic zone CTP parameters and TEG indicators for different stroke etiologies (Mean±SD)
表4 NIHSS评分与缺血区CTP参数和TEG各项指标的相关性
Tab.4 Correlation between NIHSS score and ischemic zone CTP parameters and TEG indicators
表5 急性前循环脑梗死患者早期神经功能恶化影响因素的多因素二元Logistic回归分析
Tab.5 Multivariate binary Logistic regression analysis of the impact of early neurological deterioration in patients with acute anterior circulation cerebral infarction
图1 缺血区TTP、CBV、CBF、KT、RT及5项指标联合预测急性前循环脑梗死患者早期神经功能恶化的ROC曲线
Fig.1 ROC curve for predicting early neurological deterioration in patients with acute anterior circulation cerebral infarction using TTP,CBV,CBF,KT,RT,and five combinations
表6 CTP参数和TEG相关指标在预测急性前循环脑梗死患者早期神经功能恶化中的预测效能
Tab.6 Predictive efficacy of CTP and TEG related indicators in predicting early neurological deterioration in patients with acute anterior circulation cerebral infarction
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