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中华神经创伤外科电子杂志

中华神经创伤外科电子杂志 ›› 2019, Vol. 05 ›› Issue (06) : 353 -357. doi: 10.3877/cma.j.issn.2095-9141.2019.06.008

所属专题： 文献；

临床研究

不同剂量阿托伐他汀钙联合双抗对急性脑梗死患者神经功能恢复的影响
杨亦炳1, 张霞1,†(), 张照华1, 霍君明1, 王文娟1   
  1. 1. 510280　广州，南方医科大学珠江医院药学部
  • 收稿日期:2019-05-15 出版日期:2019-12-15
  • 通信作者: 张霞

Effect of different doses of atorvastatin calcium combined with double antibody on the recovery of neurological function in patients with acute cerebral infarction

Yibing Yang1, Xia Zhang1,†(), Zhaohua Zhang1, Junming Huo1, Wenjuan Wang1   

  1. 1. Department of Pharmacy, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, China
  • Received:2019-05-15 Published:2019-12-15
  • Corresponding author: Xia Zhang
  • About author:
    Corresponding author: Zhang Xia, Email:
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杨亦炳, 张霞, 张照华, 霍君明, 王文娟. 不同剂量阿托伐他汀钙联合双抗对急性脑梗死患者神经功能恢复的影响[J]. 中华神经创伤外科电子杂志, 2019, 05(06): 353-357.

Yibing Yang, Xia Zhang, Zhaohua Zhang, Junming Huo, Wenjuan Wang. Effect of different doses of atorvastatin calcium combined with double antibody on the recovery of neurological function in patients with acute cerebral infarction[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2019, 05(06): 353-357.

目的

探讨不同剂量阿托伐他汀钙联合双抗对急性脑梗死患者神经功能恢复的影响。

方法

选取2015年1月至2018年5月在南方医科大学珠江医院神经外科中心进行治疗的急性脑梗死患者共164例，采用随机数字法将患者分为研究组和对照组，每组82例，其中对照组采用小剂量阿托伐他汀钙联合双抗进行治疗，研究组采用大剂量阿托伐他汀钙联合双抗进行治疗。对比2组患者治疗前后的神经功能、血管内皮功能、血脂水平及神经体内指标。

结果

研究组的各项神经功能均优于对照组，差异具有统计学意义（P<0.05）。2组患者治疗前的各项功能指数比较，差异均无统计学意义（P>0.05）；治疗后2组患者的血管内皮功能较治疗前有一定的改善，但组间比较差异无统计学意义（P>0.05）；治疗后研究组患者的甘油三酯、血清总胆固醇、低密度脂蛋白胆固醇及高敏C反应蛋白水平的改善程度均优于对照组，差异有统计学意义（P<0.05），2组治疗后的高密度脂蛋白胆固醇水平比较，差异无统计学意义（P>0.05）。治疗后研究组患者的白细胞介素6水平明显低于对照组，差异有统计学意义（P<0.05），治疗后2组患者的血蓝蛋白与白细胞介素8水平比较，差异均无统计学意义（P>0.05）。

结论

大剂量的阿托伐他汀钙联合双抗对于急性脑梗死患者的神经功能恢复有着积极的作用，对其他体内水平有良好的影响，有利于改善预后。

关键词: 阿托伐他汀钙, 神经功能, 急性脑梗死
Objective

To explore the effect of different doses of atorvastatin calcium combined with double antibody on the recovery of neurological function in patients with acute cerebral infarction.

Methods

A total of 164 patients with acute cerebral infarction who were treated in Neurosurgical Center, Zhujiang Hospital, Southern Medical University from January 2015 to May 2018 were randomly divided into study group and control group, with 82 cases in each group. Among them, the control group was treated with low-dose atorvastatin calcium combined with double antibodies, the study group was treated with high-dose atorvastatin calcium combined with double antibodies. Compare the neurological function, vascular endothelial function, blood lipid level and neurosomatic index of the two groups before and after treatment.

Results

The neurological function of the study group was better than that of the control group, and the difference between the two groups was statistically significant (P<0.05). Before treatment, there was no significant difference between the two groups (P>0.05); after treatment, the vascular endothelial function of the two groups was improved, but there was no significant difference between the two groups (P>0.05); after treatment, the improvement of triglyceride, serum total cholesterol, low density lipoprotein chesterol and high sensitive C-reactive protein levels of the study group was better than that of the control group, and the difference was statistically significant (P<0.05). There was no significant difference in high density liptein cholesterol between the two groups (P>0.05). After treatment, the level of interleukin 6 in the study group was significantly lower than that in the control group, and the difference was statistically significant (P<0.05) . After treatment, there was no significant difference between hemocyanin and interleukin 8 in the two groups (P>0.05).

Conclusion

Large dose of atorvastatin calcium combined with double anti-tumor has a positive effect on the recovery of neurological function in patients with acute cerebral infarction, has a good effect on other body levels, and is conducive to improving the prognosis.

Key words: Atorvastatin calcium, Nerve function, Acute cerebral infarction
表1 2组患者的神经功能比较
组别 例数 MCV(m/s) SCV(m/s) F波潜伏期(ms)
对照组 82 38.442±7.643 35.811±6.274 29.391±2.372
研究组 82 49.745±9.101 43.383±7.722 21.844±2.643
t值 ? 9.220 7.379 20.632
P值 ? <0.001 <0.001 <0.001
表2 2组患者治疗前后的血管内皮功能比较
组别 例数 FMD(%) IMT(mm)
治疗前 治疗后 治疗前 治疗后
对照组 82 6.141±0.733 8.674±1.242 1.570±0.311 1.412±0.271
研究组 82 6.192±0.852 8.593±1.372 1.553±0.252 1.430±0.303
t值 ? 0.560 0.544 0.631 0.622
P值 ? 0.575 0.586 0.528 0.533
表3 2组患者治疗前后的血脂水平比较
血脂指标 ? 对照组(n=82) 研究组(n=82) t值 P值
TG(mmol/L) 治疗前 2.13±0.51 2.21±0.47 1.449 0.148
治疗后 1.47±0.66 1.31±0.47 2.482 0.013
TC(mmol/L) 治疗前 5.48±0.77 5.41±0.69 0.851 0.395
治疗后 4.09±0.57 3.11±0.64 14.373 <0.001
HDL-C(mmol/L) 治疗前 1.22±0.32 1.25±0.28 0.886 0.375
治疗后 1.25±0.33 1.23±0.30 0.563 0.573
LDL-C(mmol/L) 治疗前 3.57±0.74 3.49±0.88 0.874 0.385
治疗后 2.06±0.51 1.36±0.43 13.190 <0.001
Hs-CRP(mg/L) 治疗前 14.22±1.19 14.383±1.20 1.190 0.235
治疗后 7.68±1.42 2.94±0.60 38.649 <0.001
表4 2组患者治疗前后的神经体内指标比较
组别 例数 Hcy(μmol/L) IL-6(pg/mL) IL-8(pg/mL)
治疗前 治疗后 治疗前 治疗后 治疗前 治疗后
对照组 82 11.53±5.82 17.32±8.41a 11.31±3.42 18.73±6.14a 27.34±5.42 32.322±7.43a
研究组 82 11.81±6.33 16.51±7.23a 12.10±3.24 15.43±3.83a 26.83±4.93 30.43±6.82a
t值 ? 0.334 0.689 1.634 8.362 0.654 1.804
P值 ? 0.739 0.497 0.104 <0.001 0.514 0.073
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