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中华神经创伤外科电子杂志 ›› 2022, Vol. 08 ›› Issue (01) : 51 -55. doi: 10.3877/cma.j.issn.2095-9141.2022.01.011

综述

载脂蛋白E在创伤性脑损伤中作用及机制的研究进展
毕万达1, 刘阳珷玥1, 戴双双1,()   
  1. 1. 400038 重庆,陆军军医大学基础医学院
  • 收稿日期:2021-06-03 出版日期:2022-02-15
  • 通信作者: 戴双双
  • 基金资助:
    国家自然科学基金(82071779)

Roles and mechanisms of apolipoprotein E in traumatic brain injury

Wanda Bi1, Yangwuyue Liu1, Shuangshuang Dai1,()   

  1. 1. School of Basic Medicine, Army Medical University, Chongqing 400038, China
  • Received:2021-06-03 Published:2022-02-15
  • Corresponding author: Shuangshuang Dai
引用本文:

毕万达, 刘阳珷玥, 戴双双. 载脂蛋白E在创伤性脑损伤中作用及机制的研究进展[J/OL]. 中华神经创伤外科电子杂志, 2022, 08(01): 51-55.

Wanda Bi, Yangwuyue Liu, Shuangshuang Dai. Roles and mechanisms of apolipoprotein E in traumatic brain injury[J/OL]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2022, 08(01): 51-55.

创伤性脑损伤(TBI)作为神经外科最常见的颅脑损伤疾病,具有高发病率、高致残率和高死亡率的特点。载脂蛋白E(apoE)是神经系统一类重要的载脂蛋白,在TBI的病理生理变化过程中起到了关键作用。由于apoE亚型的功能与分布具有异质性,靶向apoE治疗TBI尚有争议。本文主要就不同亚型apoE在TBI中的作用与机制作一综述,为深入研究靶向apoE的TBI治疗策略提供参考。

Traumatic brain injury (TBI), the most common brain injury disease in neurosurgery department, is characterized by high rates of morbidity and disability. Apolipoprotein E (apoE), an important type of apolipoproteins in central nervous system, plays fundamental roles in the pathophysiological processes of TBI. However, the distributions and functions differ from apoE subtypes, making it still debatable to targeting at apoE for TBI treatmennts. This article reviews the possible roles and mechanisms of different apoE subtypes in TBI, so as to provide further research in TBI treatment strategies targeting apoE.

表1 不同apoE亚型在TBI中的作用
图1 apoE、AD与TBI的关系图AD:阿尔兹海默病;apoE:载脂蛋白E;TBI:创伤性脑损伤
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