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中华神经创伤外科电子杂志 ›› 2017, Vol. 03 ›› Issue (05) : 284 -291. doi: 10.3877/cma.j.issn.2095-9141.2017.05.007

所属专题: 文献

基础研究

胶质母细胞瘤鼠双微粒体2单核苷酸多态性易感性:Meta分析
秦家骏1, 钟荣德1, 陈先震1,()   
  1. 1. 200072 上海,同济大学附属第十人民医院神经外科
  • 收稿日期:2017-09-03 出版日期:2017-10-15
  • 通信作者: 陈先震
  • 基金资助:
    上海市科学技术委员会科研计划项目(12ZR1423400)

Hereditary susceptibility with MDM2 gene single nucleotide polymorphism for glioblastoma: Meta-analysis

Jiajun Qin1, Rongde Zhong1, Xianzhen Chen1,()   

  1. 1. Department of Neurosurgery, Tenth Perples’ Hospital of Tongji University, Shanghai 200072, China
  • Received:2017-09-03 Published:2017-10-15
  • Corresponding author: Xianzhen Chen
  • About author:
    Corresponding author: Chen Xianzhen, Email:
引用本文:

秦家骏, 钟荣德, 陈先震. 胶质母细胞瘤鼠双微粒体2单核苷酸多态性易感性:Meta分析[J]. 中华神经创伤外科电子杂志, 2017, 03(05): 284-291.

Jiajun Qin, Rongde Zhong, Xianzhen Chen. Hereditary susceptibility with MDM2 gene single nucleotide polymorphism for glioblastoma: Meta-analysis[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2017, 03(05): 284-291.

目的

对鼠双微粒体(MDM2)单核苷酸多态性与胶质母细胞瘤易感性的关联进行分析。

方法

本研究在PubMed、Google Scholar、中国知网、百度学术等数据库对相关检索词组合进行不限定检索,通过文献筛选,最终确定6篇病例对照研究中的样本为试验对象,对MDM2 SNP309与肿瘤的关联性进行Meta分析。

结果

Meta分析的结果表明,MDM2 SNP309杂合和纯合突变型与胶质母细胞瘤的易感性有关联,比值比(OR)=1.23[95%置信区间(CI):1.05~1.44],I2检验P=0.288;杂合突变型尤为突出,OR=1.35(95%CI:1.05~1.73);按人种的亚组分析可知,高加索人的关联性较强,OR=1.30(95%CI:1.08~1.57),I2检验P=0.410。

结论

本研究中的Meta分析提示了MDM2 SNP309突变与胶质母细胞瘤发生的密切联系,强调了不同人种中关联程度的不同,突出了高加索人种中杂合型突变在易感性中发挥的作用。

Objective

To explore the association of MDM2 single nucleotide polymorphism with the risk of glioblastoma.

Methods

This study has searched a great number of papers using key terms based on PubMed, Google Scholar, CNKI, Baidu Scholar before screening samples. To investigate the interaction between MDM2 SNP309 and glioblastoma risk, was performed a Meta-analysis of the risk estimate on case-control studies from six qualified articles.

Results

The data we reviewed indicated that variant homozygote and heterozygote for MDM2 SNP309 were associated with an increased risk of glioblastoma by 1.23 on odds radio (OR) (95%CI: 1.05-1.44), P=0.288 by I2 test; was performed variant heterozygote of SNP309 significantly increased the risk of cancer by 1.35 on OR (95%CI: 1.05-1.73). In a stratified analysis by ethnicity, this study certified that a significant increased risk in Caucasian by 1.30 on OR(95%CI: 1.08-1.57), P=0.410 by I2 test.

Conclusion

The analysis indicate MDM2 SNP309 serves as a susceptibility marker on glioblastoma, which was clarified the different risks in ethnicity, especially in Caucasian with variant heterozygote.

图1 文献筛选流程图
表1 Newcastle-Ottawa病例对照研究研究质量评估表
表2 纳入文献一般情况分析
图8 加性模型(GG vs GA)的森林图及亚组分析
图14 加性模型(GG vs GA)的单项排除法敏感性分析
图16 加性模型(GA vs AA)的按年份发表累计Meta分析
图19 伪95%置信区间的Begg漏斗图
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