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中华神经创伤外科电子杂志 ›› 2017, Vol. 03 ›› Issue (03) : 175 -178. doi: 10.3877/cma.j.issn.2095-9141.2017.03.012

所属专题: 文献

综述

维生素D在创伤性脑损伤中神经保护作用的研究进展
崔昌萌1, 郭鑫2, 宋思新3, 刘振刚2, 江沛4,()   
  1. 1. 272029 济宁,济宁医学院附属医院神经外科
    2. 063000 唐山,华北理工大学研究生学院
    3. 271000 泰安,泰山医学院附属医院神经外科
    4. 272029 济宁市第一人民医院临床药学科
  • 收稿日期:2017-05-03 出版日期:2017-06-15
  • 通信作者: 江沛
  • 基金资助:
    2016年度国家自然科学基金项目(81602846)

Review of the neuroprotective role of vitamin D in traumatic brain injury

Changmeng Cui1, Xin Guo2, Sixin Song3, Zhengang Liu2, Pei Jiang4,()   

  1. 1. Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining 272029, China
    2. Graduate School in North China University of Science and Technology, Tangshan 063000, China
    3. Department of Neurosurgery, Affiliated Hospital of Taishan Medical University, Taian 271000, China
    4. Institute of Clinical Pharmacy and Pharmacology, Jining First People’s Hospital, Jining 272029, China
  • Received:2017-05-03 Published:2017-06-15
  • Corresponding author: Pei Jiang
  • About author:
    Corresponding author: Jiang Pei, Email:
引用本文:

崔昌萌, 郭鑫, 宋思新, 刘振刚, 江沛. 维生素D在创伤性脑损伤中神经保护作用的研究进展[J]. 中华神经创伤外科电子杂志, 2017, 03(03): 175-178.

Changmeng Cui, Xin Guo, Sixin Song, Zhengang Liu, Pei Jiang. Review of the neuroprotective role of vitamin D in traumatic brain injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2017, 03(03): 175-178.

创伤性脑损伤(TBI)是神经外科最常见的疾病之一,是45岁以下人群中最具威胁的致残、致死因素。TBI能够导致患者的认知功能缺损和精神障碍。近年来,动物实验和临床试验表明,活性形式的维生素D3(VDH)治疗能够改善TBI导致的认知功能缺损和精神障碍。因此,本文就维生素D的生理作用及VDH在TBI治疗中可能的作用机制进行综述。

Traumatic brain injury (TBI), one of the most common diseases of neurosurgery, remains high mortality and disability in the population under 45 years. TBI patients suffer permanent cognitive neurological and psychological disabilities. In recent years, basic and clinical experiments have shown that the active form of vitamin D3 (vitamin D hormone, VDH) treatment can improve TBI-induced cognitive impairment and mental disorders. Therefore, in this paper, we focused on the physiological role of vitamin D and the possible mechanism of VDH supplementation following TBI.

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