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中华神经创伤外科电子杂志 ›› 2015, Vol. 01 ›› Issue (05) : 46 -49. doi: 10.3877/cma.j.issn.2095-9141.2015.05.012

所属专题: 文献

专题笔谈

癌胚抗原相关细胞黏附分子1与肿瘤
庄国涛1, 李晋虎1, 范益民1,,*()   
  1. 1. 030001 太原,山西医科大学第一医院神经外科
  • 收稿日期:2015-04-12 出版日期:2015-10-15
  • 通信作者: 范益民

Carcinoembryonic antigenrelated cell adhesion molecule 1 and tumor

Guotao Zhuang1, Jinhu Li1, Yimin Fan1()   

  1. 1. Department of Neurosuegery, The First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2015-04-12 Published:2015-10-15
  • Corresponding author: Yimin Fan
  • About author:
    Corresponding author: Fan Yimin, Email:
引用本文:

庄国涛, 李晋虎, 范益民. 癌胚抗原相关细胞黏附分子1与肿瘤[J/OL]. 中华神经创伤外科电子杂志, 2015, 01(05): 46-49.

Guotao Zhuang, Jinhu Li, Yimin Fan. Carcinoembryonic antigenrelated cell adhesion molecule 1 and tumor[J/OL]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2015, 01(05): 46-49.

癌胚抗原相关细胞黏附分子1(CEACAM1)属于癌胚抗原超家族成员之一,与肿瘤的新生血管、淋巴管生成,肿瘤细胞的增殖、凋亡等多种生物学过程密切相关;此外还可作为多种恶性肿瘤诊断和预后的生物学标志物;近年来又有研究发现CEACAM1可以通过负性免疫调节来抑制机体的抗肿瘤免疫能力,从而导致肿瘤逃避免疫监视和免疫杀伤。本文将对CEACAM1在肿瘤发生发展中发挥的作用做一综述。

Carcinoembryonic antigenrelated cell adhesion molecule 1 (CEACAM1) is one of members of the carcinoembryonic antigen superfamily, and it is closely related with angiogenesis and lymphangion genesis of tumor, tumor cell proliferation, apoptosis, and other biological processes; in addition CEACAM1 also could be used as a biological marker of diagnosis and prognosis of multiple malignant tumor; recently, researches has found that CEACAM1 could negatively regulate immunity to suppress the anti-tumor immunocompetence, lead to tumor escapes immune surveillance and immune killing. This review summarizes the function of CEACAM1 in tumor progress.

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