切换至 "中华医学电子期刊资源库"

中华神经创伤外科电子杂志 ›› 2015, Vol. 01 ›› Issue (04) : 241 -244. doi: 10.3877/cma.j.issn.2095-9141.2015.04.012

专题笔谈

丘脑底核高频深部脑刺激治疗帕金森病的机制
潘琪1, 徐如祥2,(), 张旺明3   
  1. 1.570102 海口,海南医学院附属医院神经外科
    2.100700 北京,北京军区神经外科研究所
    3.510282 广州,南方医科大学珠江医院神经外科
  • 收稿日期:2015-02-15 出版日期:2015-08-15
  • 通信作者: 徐如祥
  • 基金资助:
    国家自然科学基金面上项目(30872662)海南医学院创新创业训练计划项目(HYCX2014024)

The research progress of the mechanisms of the high-frequency deep brain stimulation of subthalamic nuclei in Parkinson's disease

Qi Pan1, Ruxiang Xu2,(), Wangming Zhang3   

  1. 1.Department of Neurosurgery,the Affiliated Hospital of Hainan Medical College,Haikou 570102,China
    2.Institute of Neuroscience of Beijing Military Region,Beijing 100700 China
    3.Department of Neurosurgery,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China
  • Received:2015-02-15 Published:2015-08-15
  • Corresponding author: Ruxiang Xu
引用本文:

潘琪, 徐如祥, 张旺明. 丘脑底核高频深部脑刺激治疗帕金森病的机制[J]. 中华神经创伤外科电子杂志, 2015, 01(04): 241-244.

Qi Pan, Ruxiang Xu, Wangming Zhang. The research progress of the mechanisms of the high-frequency deep brain stimulation of subthalamic nuclei in Parkinson's disease[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2015, 01(04): 241-244.

深部脑刺激疗法已被广泛用于治疗多种功能性神经疾病。其中,丘脑底核高频深部脑刺激已成为帕金森病外科治疗的首选方法,可显著改善帕金森病患者的震颤、运动徐缓和肌强直三大症状。尽管该治疗方法有很好的疗效,但其作用机制目前尚未完全阐明。本文就其作用机制的研究进展作一综述。

Deep brain stimulation has been widely used in the treatment of a variety of functional neurological diseases.Among them,the high-frequency deep brain stimulation of subthalamic nuclei,which can significantly improve tremor,bradykinesia,and rigidity in patients with Parkinson's disease,has become the preferred method of surgical treatment for Parkinson's disease.Although the treatment is effective,but its mechanisms have not been fully elucidated.In this review,we summarized the mechanisms of action of the high-frequency deep brain stimulation of subthalamic nuclei.

[1]
Udupa K,Chen R.The mechanisms of action of deep brain stimulation and ideas for thefuturedevelopment[J].Prog Neurobiol,2015,19(8):S0301-0082
[2]
Benabid AL,Chabardes S,Mitrofanis J,et al.Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease[J].Lancet Neurol,2009,8(1):67-81.
[3]
Beurrier C,Bioulac B,Audin J,et al.High-frequency stimulation produces a transient blockade of voltage-gated currents in subthalamic neurons[J].J Neurophysiol,2001,85(4):1351-1356.
[4]
Lee KH,Roberts DW,and Kim U.Effect of high-frequency stimulation of the subthalamic nucleus on subthalamic neurons:an intracellular study[J].Stereotact Funct Neurosurg,2003,80(1-4):32-36.
[5]
Garcia L,D'Alessandro G,Fernagut PO,et al.Impact of high-frequency stimulation parameters on the pattern of discharge of subthalamic neurons[J].J Neurophysiol,2005,94(6):3662-3669.
[6]
Benazzouz A,Gao DM,Ni ZG,et al.Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat[J].Neuroscience,2000,99(2):289-295.
[7]
Tai CH,Boraud T,Bezard E,et al.Electrophysiological and metabolic evidence that high-frequency stimulation of the subthalamic nucleus bridles neuronal activity in the subthalamic nucleus and the substantia nigra reticulata[J].FASEB J,2003,17(13):1820-1830.
[8]
Shi LH,Luo F,Woodward DJ,et al.Basal ganglia neural responses during behaviorally effective deep brain stimulation of the subthalamic nucleus in rats performing a treadmill locomotion test[J].Synapse,2006,59(7):445-457.
[9]
Meissner W,Leblois A,Hansel D,et al.Subthalamic high frequency stimulation resets subthalamic firing and reduces abnormal oscillations[J].Brain,2005,128(Pt 10):2372-2382.
[10]
Wilson CJ.Oscillators and Oscillations in the Basal Ganglia[J].Neuroscientist.2014,109(7):113-118.
[11]
Rubin JE,McIntyre CC,Turner RS,et al.Basal ganglia activity patterns in parkinsonism and computational modeling of their downstream effects[J].Eur JNeurosci,2012,36(2):2213-2228.
[12]
Welter ML,Houeto JL,Bonnet AM,et al.Effects of highfrequency stimulation on subthalamic neuronal activity in parkinsonian patients[J].Arch Neurol,2004,61(1):89-96.
[13]
Maurice N,Thierry AM,Glowinski J,et al.Spontaneous and evoked activity of substantia nigra pars reticulata neurons during high-frequency stimulation of the subthalamic nucleus[J].JNeurosci,2003,23(30):9929-9936.
[14]
Degos B,Deniau JM,Thierry AM,et al.Neuroleptic-induced catalepsy:electrophysiological mechanisms of functional recovery induced by high-frequency stimulation of the subthalamic nucleus[J].JNeurosci,2005,25(33):7687-7696.
[15]
Chang JY,Shi LH,Luo F,et al.Studies of the neural mechanisms of deep brain stimulation in rodent models of Parkinson's disease[J].Neurosci Biobehav Rev,2008,32(3):352-366.
[16]
Galati S,Mazzone P,Fedele E,et al.Biochemical and electrophysiological changes of substantia nigra pars reticulata driven by subthalamic stimulation in patients with Parkinson's disease[J].Eur JNeurosci,2006,23(11):2923-2928.
[17]
Maltête D,Jodoin N,Karachi C,et al.Subthalamic stimulation and neuronal activity in the substantia nigra in Parkinson's disease[J].JNeurophysiol,2007,97(6):4017-4022.
[18]
Benazzouz A,Piallat B,Pollak P,et al.Responses of substantia nigra pars reticulata and globus pallidus complex to high frequency stimulation of the subthalamic nucleus in rats:electrophysiological data[J].Neurosci Lett,1995,189(2):77-80.
[19]
Xu W,Russo GS,Hashimoto T,et al.Subthalamic nucleus stimulation modulates thalamic neuronal activity[J].J Neurosci,2008,28(46):11916-11924.
[20]
Grafton ST,Turner RS,Desmurget M,et al.Normalizing motor-related brain activity:subthalamic nucleus stimulation in Parkinson disease[J].Neurology,2006,66(8):1192-1199.
[21]
Temel Y,Visser-Vandewalle V,Kaplan S,et al.Protection of nigral cell death by bilateral subthalamic nucleus stimulation[J].Brain Res,2006,1120(1):100-105.
[22]
Visser-Vandewalle V,van der Linden C,Temel Y,et al.Long-term effects of bilateral subthalamic nucleus stimulation in advanced Parkinson disease:a four year follow-up study[J].Parkinsonism Relat Disord,2005,11(3):157-165.
[23]
Chiken S and Nambu A.Mechanism of Deep Brain Stimulation:Inhibition,Excitation,or Disruption?[J].Neuroscientist,2015,10(2):1103-1108.
[24]
McIntyre CC,Grill WM,Sherman DL,et al.Cellular effects of deep brain stimulation:model-based analysis of activation and inhibition[J].JNeurophysiol,2004,91(4):1457-1469.
[25]
Windels F,Bruet N,Poupard A,et al.Effects of high frequency stimulation of subthalamic nucleus on extracellular glutamate and GABA in substantia nigra and globus pallidus in the normal rat[J].Eur JNeurosci,2000,12(11):4141-4146.
[26]
Hammond C,Ammari R,Bioulac B,et al.Latest view on the mechanism of action of deep brain stimulation[J].Mov Disord,2008,23(15):2111-2121.
[27]
Karas PJ,Mikell CB,Christian E,et al.Deep brain stimulation:a mechanistic and clinical update[J].Neurosurg Focus,2013,35(5):E1.
[28]
Montgomery EB,Jr.Effects of GPi stimulation on human thalamic neuronal activity[J].Clin Neurophysiol,2006,117(12):2691-2702.
[1] 李元子, 殷露, 何文, 肖杨, 周永进, 王雨萌, 杨静, 黄文燕, 张惠琴, 马惠姿, 杜丽娟. 动态超声弹性成像技术评估帕金森病肌强直程度的临床研究[J]. 中华医学超声杂志(电子版), 2021, 18(07): 696-700.
[2] 姬丽娅, 姬昂, 狄政莉, 熊婧, 刘志勤, 薛秀云, 费晓炜, 豆雅楠, 王利. 叶酸通过NLRP3/ASC/Caspase-1信号通路对HT22细胞拟帕金森损伤作用的研究[J]. 中华神经创伤外科电子杂志, 2022, 08(04): 196-203.
[3] 曾倩, 徐朝阳, 张丽芳. 帕金森病步态分析的研究进展[J]. 中华脑科疾病与康复杂志(电子版), 2024, 14(04): 235-238.
[4] 李红星, 彭肖肖, 张凯, 刘贻哲, 王瀚, 李超, 杜祎祎, 宗强. 双靶点脑深部电刺激术治疗原发性震颤的疗效分析[J]. 中华脑科疾病与康复杂志(电子版), 2024, 14(04): 225-229.
[5] 罗彦妮, 陈浪, 莫励华, 韦宁, 罗纯, 黎彬如. 血清CysC、Hcy水平与帕金森病伴发脑白质病变的关系[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(06): 340-345.
[6] 金刚, 李英真, 施维, 李博. 帕金森病在病理生理学中的研究进展[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(05): 315-319.
[7] 郑丽华, 钱一菁, 黄崇甄, 周春娜. 山茱萸环烯醚萜苷改善6-OHDA诱导帕金森病细胞模型的损伤[J]. 中华脑科疾病与康复杂志(电子版), 2022, 12(06): 324-331.
[8] 陈普建, 张璟, 陈芬, 陈怡伟, 余蓓蓓, 周春英. 双侧丘脑底核交叉电脉冲脑深部电刺激对帕金森病步态障碍的疗效观察[J]. 中华脑科疾病与康复杂志(电子版), 2022, 12(05): 298-301.
[9] 李嫣然, 王凯, 吴浩. 腰椎融合术后前后路联合翻修术治疗腰椎管狭窄合并帕金森病一例报道[J]. 中华脑科疾病与康复杂志(电子版), 2021, 11(05): 316-318.
[10] 李玺琳, 章邱东. 帕金森病患者胃肠功能障碍特点及其风险因素分析[J]. 中华消化病与影像杂志(电子版), 2023, 13(03): 145-149.
[11] 耿磊, 张照婷, 许磊, 黄海, 孙毅, 杨伏猛, 徐凯, 胡春峰. 帕金森病前驱期基底神经节环路磁共振弥散张量成像的应用研究[J]. 中华临床医师杂志(电子版), 2023, 17(09): 995-1003.
[12] 杨团峰, 孟雪, 王艳香, 卢葭, 孔德生, 赵元立, 刘献增. 男性帕金森病患者球海绵体肌反射初步研究[J]. 中华临床医师杂志(电子版), 2023, 17(01): 28-32.
[13] 谢艾伦, 郑冬燕, 蔡紫薇, 卢仁建, 彭永明, 张贺, 陈家隆. 鱼藤酮通过降低线粒体钙离子单向转运体蛋白表达促进多巴胺能神经元铁死亡[J]. 中华临床实验室管理电子杂志, 2023, 11(02): 71-78.
[14] 郭如烨, 孟黎明, 陈楠, 宋玉莹, 尹海燕, 郭岩. Apelin/APJ系统对帕金森病模型的神经保护作用及机制研究进展[J]. 中华诊断学电子杂志, 2023, 11(04): 276-282.
[15] 韩远远, 于紫涵, 杨玲, 程弘禹, 宋春杰. C反应蛋白与白蛋白比值和中性粒细胞与淋巴细胞比值对老年帕金森病的诊断价值[J]. 中华老年病研究电子杂志, 2023, 10(01): 14-19.
阅读次数
全文


摘要