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中华神经创伤外科电子杂志 ›› 2017, Vol. 03 ›› Issue (05) : 300 -304. doi: 10.3877/cma.j.issn.2095-9141.2017.05.011

所属专题: 文献

综述

骨髓基质干细胞在脑缺血疾病治疗的新进展
项永生1, 徐如祥1,()   
  1. 1. 100700 北京,陆军总医院附属八一脑科医院
  • 收稿日期:2016-06-13 出版日期:2017-10-15
  • 通信作者: 徐如祥
  • 基金资助:
    国家自然科学基金(81671189); 全军医学科研十二五重点课题(BWS11J002)

New progress of bone marrow mesenchymal stem cells in the treatment of cerebral ischemic diseases

Yongsheng Xiang1, Ruxiang Xu1,()   

  1. 1. Affiliated Bayi Brain Hospital, PLA General Hospital, Beijing 100700, China
  • Received:2016-06-13 Published:2017-10-15
  • Corresponding author: Ruxiang Xu
  • About author:
    Corresponding author: Xu Ruxiang, Email:
引用本文:

项永生, 徐如祥. 骨髓基质干细胞在脑缺血疾病治疗的新进展[J]. 中华神经创伤外科电子杂志, 2017, 03(05): 300-304.

Yongsheng Xiang, Ruxiang Xu. New progress of bone marrow mesenchymal stem cells in the treatment of cerebral ischemic diseases[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2017, 03(05): 300-304.

成人骨髓基质干细胞是源于骨髓的一种多潜能成体干细胞。它们的移植改善脑缺血模型和脊髓损伤模型的机制可能包括替换受损细胞,神经功能保护作用,诱导轴突生长和促进新生血管形成。其应用于细胞治疗的主要优势在于其可以自体移植,因而不存在胚胎干细胞移植所存在的免疫排斥、伦理学及致瘤性等方面的限制;不像神经干细胞主要位于脑室下带、海马等结构中,因而细胞来源有限,获得困难。因此,这种干细胞移植疗法可能在未来的临床治疗具有重大意义。

Adult bone marrow stromal stem cells (hBMSCs) is a kind of multi potential adult stem cells derived from bone marrow. The model mechanisms of transplantation to improve cerebral ischemia model and spinal cord injury model may include replacing damaged cells, protective effect of nerve function, the induction of axon growth, and the formation of new blood vessels. Its main advantage is that it can be used in cell therapy, so there is no limit to the immune rejection, ethical problems and tumorigenicity caused by embryonic stem cell transplantation; its material is easy to be obtained, unlike neural stem cells, which are mainly located in the lower zone of the brain and hippocampus, the cell source is limited, so it is difficult to obtained. Therefore, this stem cell transplantation therapy may be of great significance in the future clinical treatment.

图1 成人骨髓基质干细胞注射后梗塞灶体积的减小并获得功能性恢复
图2 自体骨髓间充质干细胞原理流程图
图3 12例脑卒中患者静脉注射自体骨髓基质干细胞的数据统计
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