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中华神经创伤外科电子杂志 ›› 2016, Vol. 02 ›› Issue (04) : 198 -201. doi: 10.3877/cma.j.issn.2095-9141.2016.04.002

所属专题: 文献

临床研究

RET的表达与生长激素型垂体腺瘤患者生长激素水平的相关性分析
田沁涛1, 黑悦1, 伊西才1, 魏礼洲1, 王博晨1, 刘卫平1,()   
  1. 1. 710032 西安,第四军医大学附属西京医院神经外科
  • 收稿日期:2016-03-18 出版日期:2016-08-15
  • 通信作者: 刘卫平
  • 基金资助:
    陕西省科技统筹基金资助项目(2013KTCL03-08)

Analysis of the correlation of RET expression with growth hormone level of patients with growth hormone-secreting pituitary adenoma

Qintao Tian1, Yue Hei1, Xicai Yi1, Lizhou Wei1, Bochen Wang1, Weiping Liu1,()   

  1. 1. Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
  • Received:2016-03-18 Published:2016-08-15
  • Corresponding author: Weiping Liu
  • About author:
    Corresponding author: Liu Weiping, Email:
引用本文:

田沁涛, 黑悦, 伊西才, 魏礼洲, 王博晨, 刘卫平. RET的表达与生长激素型垂体腺瘤患者生长激素水平的相关性分析[J/OL]. 中华神经创伤外科电子杂志, 2016, 02(04): 198-201.

Qintao Tian, Yue Hei, Xicai Yi, Lizhou Wei, Bochen Wang, Weiping Liu. Analysis of the correlation of RET expression with growth hormone level of patients with growth hormone-secreting pituitary adenoma[J/OL]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2016, 02(04): 198-201.

目的

探讨RET的表达和单纯生长激素型垂体腺瘤(GH-PA)术后缓解情况、术后GH水平的相关性。

方法

收集并随访2010年4月至2013年4月收治于第四军医大学附属西京医院神经外科的单纯GH-PA经鼻蝶内镜手术患者20例(不缓解10例、即刻缓解6例、延迟缓解4例),监测术前、术后1周、3个月和1年血清GH水平,并取病理标本采用免疫组化检测RET的表达。

结果

延迟缓解患者RET表达水平相比即刻缓解、不缓解患者较低(P<0.05);RET的表达水平与GH激素水平(术前、术后3个月、术后1年)无显著相关性(P>0.05),但与术后GH激素水平的升高(GH1年~GH1周)呈正相关(P<0.05)。

结论

RET表达水平一定程度上能够预测患者的延迟缓解,且与术后GH激素水平升高正相关。

Objective

To investigate the correlation of RET expression with postoperative remission and growth hormone levels of patient with growth hormone-secreting pituitary adenoma(GH-PA).

Methods

Collected and followed up 20 patients (no remission 10, immediate remission 6, delayed remission 4) underwent transsphenoidal endoscopic surgery for GH-PA from from april 2010 to april 2013 in Xijing Hospital, Fourth Military Medical University to measure the changes of GH levels at different time points (before surgery, 1 week, 3month and 1 year after surgery), and the specimen were collected for RET immunohistochemical staining.

Results

The level of RET expression in the delayed remission ones tend to be lower than no remission and immediate remission groups (P<0.05). There is no significant relationship between RET expression and GH levels before, 3 months and 1 year after surgery (P>0.05), however the GH elevation (1 year-1 week) tend to have a positive relationship with RET expression.

Conclusion

RET expression to some degree helps predict delayed remission, and tend to have a positive relationship with GH elevation after surgery in GH-PA patients.

表1 本研究中患者的一般资料
图1 RET免疫组化染色示例(标尺所示为50 μm)
图2 RET表达水平(等级)和血清生长激素(ng/ml)变化的散点图与相关性
表2 患者术前术后各时间点生长激素水平变化(ng/ml)和相应的RET表达水平(0~5)
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