切换至 "中华医学电子期刊资源库"

中华神经创伤外科电子杂志 ›› 2016, Vol. 02 ›› Issue (04) : 198 -201. doi: 10.3877/cma.j.issn.2095-9141.2016.04.002

所属专题: 文献

临床研究

RET的表达与生长激素型垂体腺瘤患者生长激素水平的相关性分析
田沁涛1, 黑悦1, 伊西才1, 魏礼洲1, 王博晨1, 刘卫平1,()   
  1. 1. 710032 西安,第四军医大学附属西京医院神经外科
  • 收稿日期:2016-03-18 出版日期:2016-08-15
  • 通信作者: 刘卫平
  • 基金资助:
    陕西省科技统筹基金资助项目(2013KTCL03-08)

Analysis of the correlation of RET expression with growth hormone level of patients with growth hormone-secreting pituitary adenoma

Qintao Tian1, Yue Hei1, Xicai Yi1, Lizhou Wei1, Bochen Wang1, Weiping Liu1,()   

  1. 1. Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
  • Received:2016-03-18 Published:2016-08-15
  • Corresponding author: Weiping Liu
  • About author:
    Corresponding author: Liu Weiping, Email:
引用本文:

田沁涛, 黑悦, 伊西才, 魏礼洲, 王博晨, 刘卫平. RET的表达与生长激素型垂体腺瘤患者生长激素水平的相关性分析[J]. 中华神经创伤外科电子杂志, 2016, 02(04): 198-201.

Qintao Tian, Yue Hei, Xicai Yi, Lizhou Wei, Bochen Wang, Weiping Liu. Analysis of the correlation of RET expression with growth hormone level of patients with growth hormone-secreting pituitary adenoma[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2016, 02(04): 198-201.

目的

探讨RET的表达和单纯生长激素型垂体腺瘤(GH-PA)术后缓解情况、术后GH水平的相关性。

方法

收集并随访2010年4月至2013年4月收治于第四军医大学附属西京医院神经外科的单纯GH-PA经鼻蝶内镜手术患者20例(不缓解10例、即刻缓解6例、延迟缓解4例),监测术前、术后1周、3个月和1年血清GH水平,并取病理标本采用免疫组化检测RET的表达。

结果

延迟缓解患者RET表达水平相比即刻缓解、不缓解患者较低(P<0.05);RET的表达水平与GH激素水平(术前、术后3个月、术后1年)无显著相关性(P>0.05),但与术后GH激素水平的升高(GH1年~GH1周)呈正相关(P<0.05)。

结论

RET表达水平一定程度上能够预测患者的延迟缓解,且与术后GH激素水平升高正相关。

Objective

To investigate the correlation of RET expression with postoperative remission and growth hormone levels of patient with growth hormone-secreting pituitary adenoma(GH-PA).

Methods

Collected and followed up 20 patients (no remission 10, immediate remission 6, delayed remission 4) underwent transsphenoidal endoscopic surgery for GH-PA from from april 2010 to april 2013 in Xijing Hospital, Fourth Military Medical University to measure the changes of GH levels at different time points (before surgery, 1 week, 3month and 1 year after surgery), and the specimen were collected for RET immunohistochemical staining.

Results

The level of RET expression in the delayed remission ones tend to be lower than no remission and immediate remission groups (P<0.05). There is no significant relationship between RET expression and GH levels before, 3 months and 1 year after surgery (P>0.05), however the GH elevation (1 year-1 week) tend to have a positive relationship with RET expression.

Conclusion

RET expression to some degree helps predict delayed remission, and tend to have a positive relationship with GH elevation after surgery in GH-PA patients.

表1 本研究中患者的一般资料
图1 RET免疫组化染色示例(标尺所示为50 μm)
图2 RET表达水平(等级)和血清生长激素(ng/ml)变化的散点图与相关性
表2 患者术前术后各时间点生长激素水平变化(ng/ml)和相应的RET表达水平(0~5)
[1]
Shin SS,Tormenti MJ,Paluzzi A, et al. Endoscopic endonasal approach for growth hormone secreting pituitary adenomas: outcomes in 53 patients using 2010 consensus criteria for remission[J]. Pituitary, 2013, 16(4): 435-444.
[2]
Schwyzer L,Starke RM,Jane JA, et al. Percent reduction of growth hormone levels correlates closely with percent resected tumor volume in acromegaly[J]. J Neurosurg, 2015, 122(4): 798-802.
[3]
Levi V,Bertani GA,Guastella C, et al. Microscopic versus endoscopic transsphenoidal surgery for pituitary adenoma: analysis of surgical safety in 221 consecutive patients[J]. Clin Otolaryngol, 2016.
[4]
孔博,张文德.内分泌激素水平监测对生长激素型垂体腺瘤患者手术远期疗效的观察[J].中华医学杂志, 2011, 91(31): 2199-2201.
[5]
Yilmaz M,Vural E,Koc K, et al. Cavernous sinus invasion and effect of immunohistochemical features on remission in growth hormone secreting pituitary adenomas[J]. Turk Neurosurg, 2015, 25(3): 380-388.
[6]
Carlsen SM,Svartberg J,Schreiner T, et al. Six-month preoperative octreotide treatment in unselected, de novo patients with acromegaly: effect on biochemistry, tumour volume, and postoperative cure[J]. Clin Endocrinol (Oxf), 2011, 74(6): 736-743.
[7]
Ichihara M,Murakumo Y,Takahashi M. RET and neuroendocrine tumors[J]. Cancer Lett, 2004, 204(2): 197-211.
[8]
Vargiolu M,Fusco D,Kurelac I, et al. The tyrosine kinase receptor RET interacts in vivo with aryl hydrocarbon receptor-interacting protein to alter survivin availability[J]. J Clin Endocrinol Metab, 2009, 94(7): 2571-2578.
[9]
中华医学会内分泌学分会,中华医学会神经外科学分会,中国垂体腺瘤协作组.中国肢端肥大症诊治指南(2013版)[J].中华医学杂志, 2013, 93(27): 2106-2111.
[10]
Zhou T,Wang F,Meng X, et al. Outcome of endoscopic transsphenoidal surgery in combination with somatostatin analogues in patients with growth hormone producing pituitary adenoma[J]. J Korean Neurosurg Soc, 2014, 56(5): 405-409.
[11]
徐涛,彭林,李昊,等.我国内镜对比显微镜下垂体瘤切除术的更新及累积荟萃分析[J].中华医学杂志, 2015, 95(41): 3378-3381.
[12]
中国垂体腺瘤协作组.中国垂体腺瘤外科治疗专家共识[J].中华医学杂志, 2015, 95(5): 324-329.
[13]
Heliovaara E,Tuupanen S,Ahlsten M, et al. No evidence of RET germline mutations in familial pituitary adenoma[J]. J Mol Endocrinol, 2010, 46(1): 1-8.
[14]
Diaz-Rodriguez E,Garcia-Rendueles AR,Ibanez-Costa A, et al. Somatotropinomas, but not nonfunctioning pituitary adenomas, maintain a functional apoptotic RET/Pit1/ARF/p53 pathway that is blocked by excess GDNF[J]. Endocrinology, 2014, 155(11): 4329-4340.
[15]
Wang X. Structural studies of GDNF family ligands with their receptors-insights into ligand recognition and activation of receptor tyrosine kinase RET[J]. Biochim Biophys Acta, 2013, 1834(10): 2205-2212.
[16]
Lloyd C,Grossman A. The AIP (aryl hydrocarbon receptor-interacting protein) gene and its relation to the pathogenesis of pituitary adenomas[J]. Endocrine, 2014, 46(3): 387-396.
[17]
Cabanillas ME,Schlumberger M,Jarzab B, et al. A phase 2 trial of lenvatinib (E7080) in advanced, progressive, radioiodine-refractory, differentiated thyroid cancer: a clinical outcomes and biomarker assessment[J]. Cancer, 2015, 121(16): 2749-2756.
[1] 袁成雪, 张宗霞, 许婷, 斯郎拉姆. 三种内镜手术治疗结肠息肉的效果及安全性观察[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 78-81.
[2] 张海涛, 康婵娟, 翟静洁. 胰管支架置入治疗急性胆源性胰腺炎效果观察[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 654-657.
[3] 张天献, 吕云福, 郑进方. 胆总管结石微创治疗进展[J]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 585-588.
[4] 侯文运, 刘恒昌, 窦利州, 陈海鹏, 郑朝旭, 王贵齐, 王锡山. 腹部无辅助切口内镜引导下取标本的腹腔镜辅助右半结肠癌根治术(保留回盲部)(附视频)[J]. 中华结直肠疾病电子杂志, 2023, 12(05): 436-440.
[5] 刘政委, 仪立志, 尹夕龙, 孔文龙, 纠智松, 张文源. 锥颅血肿外引流与神经内镜手术治疗老年基底节区高血压性脑出血的疗效分析[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(05): 299-303.
[6] 侯超, 潘美辰, 吴文明, 黄兴广, 李翔, 程凌雪, 朱玉轩, 李文波. 早期食管癌及上皮内瘤变内镜黏膜下剥离术后食管狭窄的危险因素[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 383-387.
[7] 孙欣欣, 刘军, 陈超伍, 孙超. 超声内镜引导细针穿刺抽吸术在胰腺占位性病变中的应用[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 418-421.
[8] 高显奎, 赵太云, 陆兴俊, 张洪领, 房修罗, 闫碧春, 王胤, 王永翠, 刘苗苗, 冉若男. 内镜电凝止血与组织胶注射治疗上消化道溃疡伴出血的疗效观察[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 452-455.
[9] 张政赢, 鞠阳, 刘晓宁. 二甲双胍对2型糖尿病患者大肠腺瘤术后复发的影响[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 485-488.
[10] 丁亚梅, 田野, 钱进, 陈梅, 季鸿颖. 良性胃溃疡出血患者内镜治疗术后再出血的危险因素分析[J]. 中华消化病与影像杂志(电子版), 2023, 13(05): 322-325.
[11] 许灿, 周鹏哲, 朱宁, 穆维娜. 超声内镜与磁共振胰胆管成像对胆总管泥沙样结石的诊断价值[J]. 中华消化病与影像杂志(电子版), 2023, 13(05): 359-362.
[12] 邱春华, 张志宏. 1108例小肠疾病的临床诊断及检查策略分析[J]. 中华临床医师杂志(电子版), 2023, 17(9): 948-954.
[13] 王亚丹, 吴静, 黄博洋, 王苗苗, 郭春梅, 宿慧, 王沧海, 王静, 丁鹏鹏, 刘红. 白光内镜下结直肠肿瘤性质预测模型的构建与验证[J]. 中华临床医师杂志(电子版), 2023, 17(06): 655-661.
[14] 孟科, 李燕, 闫婧爽, 闫斌. 胶囊内镜胃通过时间的影响因素分析[J]. 中华临床医师杂志(电子版), 2023, 17(06): 671-675.
[15] 陈柯豫, 黄艳齐, 张玲利. 同时性多发早期食管癌及高级别上皮内瘤变的危险因素分析[J]. 中华临床医师杂志(电子版), 2023, 17(05): 524-528.
阅读次数
全文


摘要