切换至 "中华医学电子期刊资源库"

中华神经创伤外科电子杂志 ›› 2016, Vol. 02 ›› Issue (03) : 181 -183. doi: 10.3877/cma.j.issn.2095-9141.2016.03.015

所属专题: 文献

专题笔谈

槲皮素对脑卒中神经损伤修复的研究进展
易波1, 戴宜武2,()   
  1. 1. 450007 郑州,郑州市中心医院神经外科
    2. 100700 北京,陆军总医院附属八一脑科医院
  • 收稿日期:2015-12-01 出版日期:2016-06-15
  • 通信作者: 戴宜武

Research progress of Quercetin in stroke for nerve injury repair

Bo Yi1, Yiwu Dai2,()   

  1. 1. Department of Neurosurgery, Central Hospital of Zhengzhou, 450007 Zhengzhou, China
    2. The Affiliated Bayi Brain Hospital, The PLA Army General Hospital 100700 Beijin, China
  • Received:2015-12-01 Published:2016-06-15
  • Corresponding author: Yiwu Dai
  • About author:
    Corresponding author: Dai Yiwu, Email:
引用本文:

易波, 戴宜武. 槲皮素对脑卒中神经损伤修复的研究进展[J]. 中华神经创伤外科电子杂志, 2016, 02(03): 181-183.

Bo Yi, Yiwu Dai. Research progress of Quercetin in stroke for nerve injury repair[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2016, 02(03): 181-183.

槲皮素是一种在多种植物、中药材中存在的黄酮类化合物,具有抗氧化、抗炎、抗肿瘤和神经保护等药理作用。脑卒中后引发的多种继发性损伤对脑卒中的治疗有诸多不可预知的干扰。目前,多项研究表明槲皮素在脑卒中相关损伤的病理生理过程中可以起到重要的神经保护作用。本文就近年来槲皮素对脑卒中神经损伤修复的研究进行综述。

Quercetin, a flavonoid widely distributed in various herbs, fruits and vegetables, has long been used as a component in some traditional Chinese medicines as antioxidants, anti-inflammatory and anti-tumor agents. Secondary injury from ICH (Intracerebral hemorrhage) has many unpredictable interference in stroke treatment. Recently, researchers showed that quercetin treatment offered beneficial effects in many aspects of ICH-related brain damage, including overall neurological function. In the present study, we reviewed all the studies about quercetin’s founction in ICH-related neural injury.

[1]
Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group[J]. N Engl J Med, 1995, 333(24): 1581-1587.
[2]
Bivard A,Lin L,Parsonsb MW. Parsonsb MW. Review of stroke thrombolytics[J]. J Stroke, 2013, 15(2): 90-98.
[3]
Yetuk G,Pandir D,Bas H. Protective role of catechin and quercetin in sodium benzoate-induced lipid peroxidation and the antioxidant system in human erythrocytes in vitro[J]. ScientificWorld Journal, 2014, 12, 2014: 874824.
[4]
Wu Z,Zhao J,Xu H, et al. Maternal quercetin administration during gestation and lactation decrease endoplasmic reticulum stress and related inflammation in the adult offspring of obese female rats[J]. Eur J Nutr, 2014, 53(8): 1669-1683.
[5]
Appari M,Babu KR,Kaczorowski A, et al. Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition[J]. Int J Oncol, 2014, 45(4): 1391-1400
[6]
Choi YJ,Kang JS,Park JH, et al. Polyphenolic flavonoids differ in their antiapoptotic efficacy in hydrogen peroxide-treated human vascular endothelial cells[J]. J Nutr, 2003, 133(4): 985-991.
[7]
Özyurt H,Çevik Ö,Özgen Z, et al. Quercetin protects radiation induced DNA damage and apoptosis in kidney and bladder tissues of rats[J]. Free Radi Res, 2014, 48(10): 1247-1255.
[8]
Chang Y,Huang WJ,Tien LT, et al. Ginsenosides Rg1 and Rb1 enhance glutamate release through activation of protein kinase A in rat cerebrocortical nerve terminals(synaptosomes)[J]. Eur J. Pharmacol, 2008, 578(1): 28-36.
[9]
Lu J,Wu DM,Zheng YL, et al. Quercetin activates AMPactivated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity[J]. J Pathol, 2010, 222(2): 199-212.
[10]
Mu LJ,Ding P,Wang CQ. In vitro effect of stromal cell derived factor-1 on the migration of neural stem cells[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 27: 5058-5062.
[11]
Sharma V,Mishra M,Ghosh S, et al. Modulation of interleukin-1beta mediated inflammatory response in human astrocytes by flavonoids: implications in neuroprotection[J]. Brain Res Bull, 2007, 73(1-3): 55-63.
[12]
Su J,Wang M,Bao PH, et al. Effect of SDF-lαon the Migration of differenting NPCs[J]. Chinese Journal of Cell Biology, 2009, 31(2): 223-228.
[13]
Rueger MA,Ameli M,Li H, et al. [18F]FLT PET for non-invasive monitoring of early response to gene therapy in experimental gliomas[J]. Mol Imaging Biol, 2011, 13(3): 547-557.
[14]
Arredondo F,Echeverry C,Abin-Carriquiry JA, et al. After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult[J]. Free Radic Biol Med, 2010, 49(5): 738-747.
[15]
Zhang ZJ,Cheang LC,Wang MW, et al. Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and pro-inflammation gene expression in PC12 cells and in zebrafish[J]. Int J Mol Med, 2011, 27(2): 195-203.
[16]
Silva B,Oliveira PJ,Dias A, et al. Quercetin, kaempferol and biapigenin from Hypericum perforatum are neuroprotective against excitotoxic insults[J]. Neurotox Res, 2008, 13(3-4): 265-279.
[17]
肖东,顾振纶.槲皮素对血小板激活时胞浆游离钙的影响[J].苏州医学院学报, 1995, 01: 40-41.
[18]
Plotnikov MB,Aliev OI,Maslov MJ, et al. Correction of haemorheological disturbances in myocardial infarction by diquertin and ascorbic acid[J]. Phytother Res, 2003, 17(1): 86-88.
[19]
Hubbard GP,Wolffram S,Lovegrove JA, et al. Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans[J]. J Thromb Haemost, 2004, 2(12): 2138-2145.
[20]
Zhang Y,Yi B,Ma J, et al. Quercetin Promotes Neuronal and Behavioral Recovery by Suppressing Inflammatory Response and Apoptosis in a Rat Model of Intracerebral Hemorrhage[J]. Neurochem Res, 2015, 40(1): 195-203.
[1] 陈山林, 魏绮珮, 刘畅. 腕关节假体:路在何方?[J]. 中华损伤与修复杂志(电子版), 2023, 18(06): 469-475.
[2] 仇申强, 王增涛, 郝丽文, 陈超, 刘林峰, 张迪. 拇手指全形再造二期整形的效果观察[J]. 中华损伤与修复杂志(电子版), 2023, 18(06): 485-490.
[3] 张健, 刘小龙, 查天建, 姚俊杰, 王傑. 富含血小板血浆联合异种脱细胞真皮基质修复糖尿病足缺血性创面的临床效果[J]. 中华损伤与修复杂志(电子版), 2023, 18(06): 503-506.
[4] 朴广昊, 李屹洲, 刘瑞, 赵建民, 王凌峰. 皮肤撕脱伤撕脱皮瓣活力早期评估与修复的研究进展[J]. 中华损伤与修复杂志(电子版), 2023, 18(06): 528-532.
[5] 张熙浩, 陈作观, 李拥军. 钝性主动脉损伤诊治的研究进展[J]. 中华损伤与修复杂志(电子版), 2023, 18(05): 438-441.
[6] 李芸, 乔栒柏, 邓华颉, 游云华. 增材制造Ti-6Al-4V钛合金种植体在牙缺失种植修复中的临床应用[J]. 中华口腔医学研究杂志(电子版), 2023, 17(05): 359-364.
[7] 叶长缨, 谢静, 丁桂聪. 乳牙龋病的过渡性治疗研究进展[J]. 中华口腔医学研究杂志(电子版), 2023, 17(05): 365-370.
[8] 王得晨, 杨康, 杨自杰, 归明彬, 屈莲平, 张小凤, 高峰. 结直肠癌微卫星稳定状态和程序性死亡、吲哚胺2,3-双加氧酶关系的研究进展[J]. 中华普通外科学文献(电子版), 2023, 17(06): 462-465.
[9] 王博, 郭利君, 李二强, 张贺林, 徐鹏, 杨晓春. 消化道与口腔黏膜组织在输尿管重建中的研究进展[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(05): 434-439.
[10] 钟文文, 李科, 刘碧好, 蔡炳, 脱颖, 叶雷, 马波, 瞿虎, 汪中扬, 王德娟, 邱剑光. 不同比例聚乳酸/丝素蛋白复合支架在兔尿道缺损修复中的疗效[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(05): 516-522.
[11] 廖家权, 吴波, 唐昌敏. 体外冲击波联合肌电生物反馈对脑卒中后足下垂的影响[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(05): 286-292.
[12] 王延召, 牛鹏飞, 丁长民, 高庆坤, 高兆亚, 安柯, 翟志超, 曾庆敏, 黄文生, 雷福明, 顾晋. 结直肠癌致腹壁巨大缺损的一期修补经验(附13例报告)[J]. 中华临床医师杂志(电子版), 2023, 17(05): 557-561.
[13] 孙畅, 赵世刚, 白文婷. 脑卒中后认知障碍与内分泌激素变化的关系[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 471-476.
[14] 张许平, 刘佳成, 张舸, 杜艳姣, 李韶, 商丹丹, 王浩, 李艳, 段智慧. CYP2C19基因多态性联合血栓弹力图指导大动脉粥样硬化型非致残性缺血性脑血管事件患者抗血小板治疗的效果[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 477-481.
[15] 杨海华, 袁景林, 周晓梅, 牛军伟. RNF213基因突变所致烟雾病一家系病例临床分析并文献复习[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 495-498.
阅读次数
全文


摘要