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中华神经创伤外科电子杂志 ›› 2016, Vol. 02 ›› Issue (01) : 41 -44. doi: 10.3877/cma.j.issn.2095-9141.2016.01.011

所属专题: 文献

专题笔谈

CEACAM1参与调控肿瘤免疫的研究进展
王亚周1, 李晋虎1, 苗旺1, 范益民1,()   
  1. 1. 030001 太原,山西医科大学第一临床医学院神经外科
  • 收稿日期:2015-12-14 出版日期:2016-02-15
  • 通信作者: 范益民
  • 基金资助:
    山西省卫计委科研课题(2015025); 山西省基础研究计划(青年科技研究基金)项目(编号:2012021035-4)

CEACAM1 in the regulation of tumor immunity

Yazhou Wang1, Jinhu Li1, Wang Miao1, Yimin Fan1,()   

  1. 1. Department of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2015-12-14 Published:2016-02-15
  • Corresponding author: Yimin Fan
  • About author:
    Corresponding author: Fan Yimin, Email:
引用本文:

王亚周, 李晋虎, 苗旺, 范益民. CEACAM1参与调控肿瘤免疫的研究进展[J]. 中华神经创伤外科电子杂志, 2016, 02(01): 41-44.

Yazhou Wang, Jinhu Li, Wang Miao, Yimin Fan. CEACAM1 in the regulation of tumor immunity[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2016, 02(01): 41-44.

癌胚抗原相关黏附分子1(CEACAM1)是一种免疫球蛋白样跨膜蛋白,属于免疫球蛋白超家族,广泛表达于内皮细胞、上皮细胞、粒细胞、淋巴细胞和肿瘤细胞。近年来,随着肿瘤免疫学的快速发展,目前认为CEACAM1在包括非小细胞肺癌、黑色素瘤、结直肠癌和胰腺癌等在内的多种恶性肿瘤中扮演着重要角色,其能调控机体对肿瘤的免疫杀伤能力,参与肿瘤的免疫逃逸。因此,了解CEACAM1分子在免疫系统中的作用,揭示它参与肿瘤免疫的分子机制,探索其作为肿瘤免疫治疗靶点的可能性。

Carcinoembryonic antigen-related cell adhesion molecule 1(CEACAM1) is a kind of Ig-like membrane protein, which belongs to the immunoglobulin superfamily and can be widely detected on endothelia, epithelia, granulocytes, lymphocytes and tumor cells. Over the years, with the rapid development of tumor immunology, it is now recognized that CEACAM1 plays an important role in multiple malignant tumors, includes non-small cell lung cancer, melanoma, colorectal cancer and pancreatic cancer. This protein can mediate anti-tumor immune ability of the body and assist the immune escape of the tumors. Thus, we need to get a full understand of the functions of CEACAM1 in immunology, to reveal the mechanism of its role and to explore its possibility as a target of tumor immunotherapy.

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